9:00 – 10:40 Oral presentations - Chairpersons : Lardinois Cecile and Leroy Emilie
9:00 Distinct ALL - associated JAK3 mutants exhibit different cytokine - receptor requirements and JAK - inhibitor specificities (Losdyck Elisabeth).
9:20 Cytokine Receptors Type I Activation by The Chaperone Calreticulin Mutants in Myeloptoliferative Neoplasms (Chachoua Ilyas).
9:40 Rnase by Theiler’s virus L* protein (Drappier Melissa).
10:00 Interaction with and activation of RSK explain nucleoporin hyperphosphorylation induced by TMEV leader protein (Peeters Michael)
10:20 Unmasking of the signaling pathways that lead to the constitutive expression of IDO1 in human cancer cells. (Hennequart Marc)
10:40 – 11:00 Coffee Break
11:00 - 12:40 Oral presentations - Chairpersons : Delmarcelle Anne-Sophie and Szewczyk Joanna
11:00 Segregation of endogenous sphingomyelin and cholesterol into submicrometric domains at the living erythrocyte membrane. (Carquin Melanie)
11:20 Cystinosis : testing endocytosis-‐based injury with double megalin/cystinosin KO mice & exploring stem cell correction. (Janssens Virginie)
11:40 PI3K - III/Vps34: a link between apical endocytosis and epithelial polarity ? (Grieco Giuseppina)
12:00 Unraveling the function of a new class of thioredoxins in bacteria (Goemans Camille)
12:20 Identification of new proteins interacting with thioredoxin by modulating the redox state of the cytoplasm in E. Coli (Arts Isabelle)
12:40 – 13:40 Lunch and Poster Viewing
13:40 - 15:20 Oral presentations - Chairpersons : Dedobbeleer Olivier and Cochez Perrine
13:40 Do tumor - infiltrating CD8+ T - cells recognize human breast carcinomas? (Schröder David)
14:00 Preclinical study of TDO inhibition to promote tumor rejection. (Schramme Florence)
14:20 Gecko Footprinter: a user - friendly dedicated tool for analyzing CRISPR libraries high - throughput sequencing data. (Bricard Orian) Chronic stimulation and T cell dysfunction. (Bigirimana René)
14:40 Monoclonal antibodies against GARP/TGF - β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo. (Liénart Stephanie)
15:20 – 16:20 Coffee Break and and Poster Viewing
16:20 - 18:00 Oral presentations - Chairpersons : Schlögel Matthieu and Tahay Gaëlle
16:20 The kinase ATR controls basal dCK activity and dCK activation after replication stress. (Beyaert Maxime)
16:40 Metabolite repair is required for the harmonious coexistence of glycolysis and the pentose phosphate pathway (Baldin Franscesca).
17:00 AMPK antagonizes hepatic glucagon action via phosphorylation - induced activation of cyclic nucleotide phosphodiesterase 4B. (Johanns Manuel)
17:20 Targeting AMP - metabolizing enzymes AMPD1, cN - 1A and cN - II as a strategy for AMPK activation. (Kviklyte Samanta)
17:40 DNA hypomethylation in tumors induces activation of pro - metastatic miR - 105 and TET - targeting miR - 767. (Van Tongelen Aurélie)
18:00 – 19:00 Drink
