LIST OF PUBLICATIONS

     

    2018 & in press

    1. Grieco G, Janssens V, Gaide Chevronnay HP, N’Kuli F, Van Der Smissen P, Wang TS, Shan J, Vainio S, Bilanges B, Jouret F, Vanhaesebroeck B, Pierreux CE, Courtoy PJ. Suppression of Vps34 PI 3-kinase activity in kidney proximal tubules abrogates apical trafficking and causes a Fanconi syndrome. Scientific Reports (2018), In press.
    2. Leonard C, Pollet H, Vermylen C, Gov NS, Tyteca D, Mingeot-Leclercq MP. Tuning of differential lipid order between submicrometric domains and surrounding membrane upon erythrocyte reshaping. Cell Physiol Biochem (2018), In press.
    3. Verstraeten SL, Albert M, Paquot A, Muccioli GG, Tyteca D, Mingeot-Leclercq MP. Membrane cholesterol delays cellular apoptosis induced by Ginsenoside Rh2, a steroid saponin. Toxicol Appl Pharmacol. (2018), 352:59-67.
    4. Degosserie J, Heymans C, Spourquet C, Halbout M, Van Der Smissen P, Vertommen D, Courtoy PJ, Tyteca D, Pierreux CE. Extracellular vesicles from endothelial progenitor cells promote thyroid follicle formation. J Extracellular Vesicles (2018), 7(1):1487250.
    5. Demarez C, Gérard C, Cordi S, Poncy A, Achouri Y, Dauguet N, Rosa DA, Gunning PT, Manfroid I, Lemaigre FP. MiR-337-3p controls hepatobiliary gene expression and transcriptional dynamics during hepatic cell differentiation. Hepatology (2018), 67, 313-327.

    2017

    1. Milosevic TV, Payen VL, Sonveaux P, Muccioli GG, Tulkens PM, Van Bambeke. Mitochondrial Alterations (Inhibition of Mitochondrial Protein Expression, Oxidative Metabolism and Ultrastructure) Induced by Linezolid and Tedizolid at Clinically-relevant Concentrations in cultured Human HL-60 promyelocytes and THP-1 monocytes. Antimicrob Agents Chemother. (2017), pii: AAC.01599-17.
    2. Leonard C, Conrard L, Guthmann M, Pollet H, Carquin M, Vermylen C, Gailly P, Van Der Smissen P, Mingeot-Leclercq MP, Tyteca D. Contribution of plasma membrane lipid domains to red blood cell (re)shaping. Sci Rep. (2017), 7(1):4264.
    3. Coomans de Brachène A, Dif N, de Rocca Serra A, Bonnineau C, Velghe AI, Larondelle Y, Tyteca D, Demoulin JB. PDGF-induced fibroblast growth requires monounsaturated fatty acid production by stearoyl-CoA desaturase. FEBS Open Bio. (2017), 7(3):414-423.
    4. Bulanova EA, Koudan EV, Degosserie J, Heymans C, Pereira FD, Parfenov VA, Sun Yi, Wang Qi, Akhmedova SA, Sergeeva NS, Frank GA, Khesuani YD, Pierreux CE, Mironov VA. Bioprinting of functional and vascularized mouse thyroid gland construct. Biomaterials (2017), 9:034105.

    2016

    1. Cordi S, Godard C, Saandi T, Jacquemin P, Monga SP, Colnot S, Lemaigre FP. Role of b-catenin in development of bile ducts. Differentiation (2016), 91, 42-49.
    2. Corritore E, Lee YS, Pasquale V, Liberati D, Hsu MJ, Lombard CA, Van Der Smissen P, Vetere A, Bonner-Weir S, Piemonti L, Sokal E, Lysy PA. V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A Synthetic Modified mRNA Drives Reprogramming of Human Pancreatic Duct-Derived Cells Into Insulin-Secreting Cells. Stem Cells Transl Med. (2016), 5(11):1525-1537.
    3. Terryn S, Tanaka K, Lengele JP, Olinger E, Dubois-Laforgue D, Garbay S, Kozyraki R, Van Der Smissen P, Christensen EI, Courtoy PJ, Bellanne-Chantelot C, Timsit J, Pontoglio M and Devuyst O. Tubular proteinuria in patients with HNF1a mutations: HNF1a drives endocytosis in the proximal tubule. Kidney International (2016), 89, 1075–1089.
    4. Villacorte M, Delmarcelle AS, Lernoux M, Bouquet M, Lemoine P, Bolsée J, Umans L, de Sousa Lopes SC, Van Der Smissen P, Sasaki T, Bommer G, Henriet P, Refetoff S, Lemaigre FP, Zwijsen A, Courtoy PJ, Pierreux CE. Thyroid follicle development requires Smad1/Smad5- and endothelial-dependent basement membrane assembly. Development (2016), 143, 1958-1970.
    5. Demarez C, Hubert C, Sempoux C, Lemaigre FP. Expression of molecular differentiation markers does not correlate with histological differentiation grade in intrahepatic cholangiocarcinoma. PLos ONE (2016), 11(6):e0157140.
    6. Augereau C, Collet L, Vargiu P, Guerra C, Ortega S, Lemaigre FP, Jacquemin P. Chronic pancreatitis and lipomatosis are associated with defective function of ciliary genes in pancreatic ductal cells. Hum Mol Gen (2016), 25, 5017-5022.
    7. Gaide Chevronnay HP, Janssens V, Van Der Smissen P, Rocca CJ, Liao XH, Refetoff S, Pierreux CE, Cherqui S, Courtoy PJ. Hematopoietic stem cells transplantation can normalize thyroid function in a cystinosis mouse model. Endocrinology (2016), 157:1363-71.
    8. Siala W, Kucharíková S, Braem A, Vleugels J, Tulkens PM, Mingeot-Leclercq MP, Van Dijck P, Van Bambeke F. The antifungal caspofungin increases fluoroquinolone activity against Staphylococcus aureus biofilms by inhibiting N-acetylglucosamine transferase. Nature Communications (2016), 7:13286.

    2015

    1. Carquin M, Conrard L, Pollet H, Van Der Smissen P, Cominelli A, Veiga-da-Cunha M, Courtoy PJ, Tyteca D. Cholesterol segregates into submicrometric domains at the living erythrocyte membrane: evidence and regulation. Cell Mol Life Sci. (2015), 72(23):4633-51.
    2. Tyteca D, Nishino T, Debaix H, Van Der Smissen P, N'Kuli F, Hoffmann D, Cnops Y, Rabolli V, van Loo G, Beyaert R, Huaux F, Devuyst O, Courtoy PJ. Regulation of macrophage motility by the water channel aquaporin-1: crucial role of M0/M2 phenotype switch. PLoS One (2015), 10(2):e0117398.
    3. Grimont A, Pinho AV, Cowley MJ, Augereau C, Mawson A, Giry-Laterrière M, Van den Steen G, Waddel N, Pajic M, Sempoux C, Wu J, Grimmond SM, Biankin AV, Lemaigre FP, Rooman I, Jacquemin P. SOX9 regulates ERBB signaling in pancreatic cancer development. Gut (2015), 64, 1790-1799.
    4. Poncy A, Antoniou A, Cordi S, Pierreux CE, Jacquemin P, Lemaigre FP. Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts. Dev. Biol. (2015), 404, 136-148.
    5. Beaudry JB, Cordi S, Demarez C, Lepreux S, Pierreux CE, Lemaigre FP. Proliferation-independent development of biliary cysts in polycystic liver diseases. PLoS ONE (2015), 10 (6): e0132295.
    6. Gaide Chevronnay HP, Janssens V, Van Der Smissen P, Liao XH, Abid Y, Nevo N, Antignac C, Refetoff S, Cherqui S, Pierreux CE*, Courtoy PJ*. A mouse model suggests two mechanisms for thyroid alterations in infantile cystinosis: decreased thyroglobulin synthesis due to endoplasmic reticulum stress/unfolded protein response and impaired lysosomal processing. Endocrinology (2015), 156:2349-64.
    7. Gohy ST, Fremgimilika C, Detry BR, Bouzin C, Gaide Chevronay H, Lecocq M, Hupin C, Weynand B, Ladjemi MZ, Pierreux CE, Birembaut P, Polette M, Pilette C. Epithelial to mesenchymal transition in the bronchial epithelium from COPD patients persists in vitro and correlates with airway fibrosis and obstruction. Eur Resp J (2015), 45:1258-72.

    2014

    1. Delmarcelle AS, Villacorte M, Hick AC, Pierreux CE. An ex vivo culture system to study thyroid development. J. Vis Exp. (2014), 6;(88).
    2. Carquin M, Pollet H, Veiga-da-Cunha M, Cominelli A, Van Der Smissen P, N’kuli F, Emonard H, Henriet P, Mizuno H, Courtoy PJ, Tyteca D. Endogenous sphingomyelin segregates into submicrometric domains in the living erythrocyte membrane. J. Lipid Research (2014), 55(7):1331-42.
    3. Koussoroplis SJ, Paulissen G, Tyteca D, Goldansaz H, Todoroff J, Barilly C, Uyttenhove C, Van Snick J, Cataldo D, Vanbever R. PEGylation of antibody fragments greatly increases their local residence time following delivery to the respiratory tract. J Control Release (2014), 187:91-100.
    4. Seth A, Ye J, Yu N, Guez F, Bedford DC, Neale GA, Cordi S, Brindle PK, Lemaigre FP, Kaestner KH, and Sosa-Pineda B. Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development (2014), 141, 538-547.
    5. Marbaix AY, Tyteca D, Niehaus TD, Hanson AD, Linster CL, Van Schaftingen E. Occurrence and subcellular distribution of the NAD(P)HX repair system in mammals. Biochem J. (2014), 15:460(1):49-58.
    6. Demotte N, Bigirimana R, Wieërs G, Stroobant V, Squifflet JL, Carrasco J, Thielemans K, Baurain JF, Van Der Smissen P, Courtoy PJ, van der Bruggen P. A short ex vivo treatment with galactomannan GM-CT-01 corrects the function of human tumor-infiltrating lymphocytes. Clin Cancer Res (2014), 20(7):1823-33.
    7. Cominelli A, Halbout M, N’Kuli F, Lemoine P, Courtoy PJ, Marbaix E*, Tyteca D*, Henriet P*. A unique C-terminal motif allows retention of matrix metalloproteinase-27 in the endoplasmic reticulum. Traffic (2014), 15(4):401-17.
    8. Gaide Chevronnay HP, Janssens V, Van Der Smissen P, N'Kuli F, Nevo N, Guiot Y, Levtchenko E, Marbaix E, Pierreux CE, Cherqui S, Antignac C, Courtoy PJ. Time-course of pathogenic and adaptative mechanisms in cystinotic mice kidneys. J Am Soc Nephrol (2014), 25(6):1256-69.
    9. Siala W, Mingeot-Leclercq M-P, Tulkens PM, Hallin M, Denis O,Van Bambeke F. Antibiotic activity against biofilms from Staphylococcus aureus clinical isolates: factors determining the activity of the investigational fluoroquinolone delafloxacin in comparison with daptomycin and vancomycin. Antimicrobial Agents and Chemotherapy (2014), 58:6385-6398.

    2013

    1. Boutin B, Tajeddine N, Van Der Smissen P,  Zanou, Van Schoor M, Mondin L,. Courtoy PJ, Tombal B and Gailly P. Androgen Deprivation and Androgen Receptor Competition by Bicalutamide InduceAutophagy of Hormone-Resistant Prostate Cancer Cells and Confer Resistance to Apoptosis. The Prostate DOI 10.1002/pros.22658 Published online in Wiley Online Library (wileyonlinelibrary.com) (2013).
    2. Gualdrón-López M, Chevalier N, Van Der Smissen P, Courtoy PJ, Rigden DJ, Michels PAM. Ubiquitination of the glycosomal matrix protein receptor PEX5 in Trypanosoma brucei by PEX4 displays novel features. Biochim Biophys Acta - Mol. Cell Res. (2013), 1833:3076-92.
    3. Liu Y, Lai YC, Hill EV, Tyteca D, Carpentier S, Ingvaldsen A, Vertommen D, Lantier L, Foretz M, Dequiedt F, Courtoy PJ, Erneux C, Viollet B, Shepherd PR, Tavaré JM, Jensen J, Rider MH. Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle. Biochem J. (2013), 15;455(2):195-206.
    4. Carpentier S, Van Der Smissen P, N’Kuli F, Grieco P, Emonard H, Bilanges B, Vanhaesebroeck B, Gaide-Chevronnay H, Pierreux CE, Tyteca D, Courtoy PJ. Phospho-inositide 3-kinase type III and dynamin are critical for apical endocytic recycling. Traffic (2013), 14(8):933-48.
    5. D’Auria L, Fenaux M, Aleksandrowicz P, Van Der Smissen P, Chantrain C, Vermylen C, Vikkula M, Courtoy PJ, Tyteca D. Micrometric segregation of fluorescent membrane lipids:relevance for endogenous lipids and biogenesis in erythrocytes. J Lipid Res. (2013), 54:1066-76.
    6. Hick AC, Delmarcelle AS, Bouquet M, Klotz S, Copetti T, Forez C, Van Der Smissen P, Sonveaux P, Feron O, Courtoy PJ, Pierreux CE. Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation. Dev Biol (2013), 381:227-40.
    7. Pierrot N, Tyteca D, D’Auria L, Dewachter I, Gailly P, Hendrickx A, Tasiaux B, El Haylani L, Muls N, N’Kuli F, Laquerrière A, Demoulin J-B, Campion D, Brion J-P, Courtoy PJ, Kienlen-Campard P, Octave J-N. Amyloid precursor protein controls cholesterol turnover needed for neuronal activity. EMBO Mol Med (2013), 5:608-625.
    8. Prévot PP, Augereau C, Simion A, Van den Steen G, Dauget N, Lemaigre FP, Jacquemin P. Let-7b and miR-495 stimulate differentiation and prevent metaplasia of pancreatic acinar cells by repressing HNF6. Gastroenterology (2013), 145 : 668-78.
    9. D'Auria L, Deleu M, Dufour S, Mingeot-Leclercq MP, Tyteca D. Surfactins modulate the lateral organization of fluorescent membrane polar lipids: a new tool to study drug:membrane interaction and assessment of the role of cholesterol and drug acyl chain length. Biochim Biophys Acta. (2013), 1828(9):2064-73.

    2012

    1. Ben Khalifa N*, Tyteca D*, Marinangeli C, Depuydt M, Collet J-F, Courtoy PJ, Renauld J-C, Constantinescu SN, Octave J-N, Kienlen-Campard P. Structural features of the KPI domain control APP dimerization, trafficking and processing (*, equal first authors). FASEB J (2012), 26:855-67.
    2. Español-Suñer R, Carpentier R, Van Hul N, Legry V, Achouri Y, Cordi S, Jacquemin P, Lemaigre F, Leclercq IA. Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice. Gastroenterology (2012), 143, 1564-1575.
    3. Feliciano PR, Gupta S, Dyszy F, Dias-Baruffi M, Costa-Filho AJ, Michels PAM, Nonato MC. Fumarate hydratase isoforms of Leishmania major: subcellular localization, structural and kinetic properties. Int J Biol Macromol. (2012), 51(1-2):25-31.
    4. Laudadio I, Manfroid I, Achouri Y, Schmidt D, Wilson MD, Cordi S, Thorrez L, Knoops L, Jacquemin P, Schuit F, Pierreux CE, Odom DT, Peers B, Lemaigre FP. A feedback loop between the liver-enriched transcription factor network and miR-122 controls hepatocyte differentiation. Gastroenterology (2012), 142, 119-29.
    5. Montano-Almendras CP, Essaghir A, Schoemans H, Varis I, Noël LA, Velghe AI, Latinne D, Knoops L, Demoulin JB. ETV6-PDGFRB and FIP1L1-PDGFRA stimulate human hematopoietic progenitor cell proliferation and differentiation into eosinophils: the role of nuclear factor-κB. Haematologica. (2012), 97(7):1064-72.
    6. Prévot PP, Simion A, Grimont A, Colletti M, Khalaileh A, Van den Steen G, Sempoux C, Xu X, Roelants V, Hald J, Bertrand L, Heimberg H, Konieczny SF, Dor Y, Lemaigre FP, Jacquemin P. Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia. Gut (2012), 61, 1723-32.
    7. Tahay G, Wiame E, Tyteca D, Courtoy PJ, Van Schaftingen E. Determinants of the enzymatic activity and the subcellular localization of aspartate N-acetyltransferase, the enzyme that synthesizes the abundant brain compound N-acetylaspartate. Biochem J (2012), 441:105-12.
    8. Verplaetse E, Gualdrón-López M, Chevalier N, Michels PAM. Studies on the organization of the docking complex involved in matrix protein import into glycosomes of Trypanosoma brucei. Biochem Biophys Res Commun. (2012), 424:781-5.
    9. 2011
    10. Raynaud P, Tate J, Callens C, Van Der Smissen P, Carpentier R, Sempoux C, Devuyst O, Pierreux C, Courtoy PJ, Dahan K, Delbecque K, Lepreux S, Pontoglio M, Guay-Woodford LM, Lemaigre FP. A classification of ductal plate malformations based on distinct pathogenic mechanisms of biliary dysmorphogenesis. Hepatology (2011), 53:1959-66.
    11. Carpentier R, Español Suñer R, Van Hul N, Kopp JL, Beaudry JB, Cordi S, Antoniou A, Raynaud P, Lepreux S, Jacquemin P, Leclercq IA, Sander M, Lemaigre FP. Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes and adult liver progenitor cells. Gastroenterology (2011), 141, 1432-1438.
    12. D’Auria L, Van Der Smissen P, Bruyneel F, Courtoy PJ, Tyteca D. Segregation of fluorescent membrane lipids into distinct submicrometric domains: evidence for large-scale phase compartmentation of natural lipids. PlosOne (2011), 6:e17021.
    13. Denamur S*, Tyteca D*, Van Bambeke F, Tulkens PM, Courtoy PJ**, Mingeot-Leclercq M-P** (*, equal first authors; **, equal last authors). Role of oxidative stress in lysosomal membrane permeabilization and apoptosis induced by gentamicin, an aminoglycoside antibiotic. Free Radical Bio Med (2011), 51:1656-65.
    14. Elens L, Tyteca D, Panin N, Courtoy PJ, Lison D, Demoulin J-B, Haufroid V. Functional defect caused by the 4544G>A SNP in ABCC2: potential impact for drug cellular disposition. Pharmacogenet Genomics (2011), 12:884-93.
    15. Selvais C, D'Auria L, Tyteca D, Perrot G, Lemoine P, Troeberg L, Dedieu S, Noël A, Nagase H, Henriet P, Courtoy PJ, Marbaix E, Emonard H. Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function. FASEB J. (2011), 25(8):2770-81.

    2010

    1. Demotte N, Wieërs G, Van Der Smissen P, Moser M, Schmidt C, Thielemans K, Squifflet J-L, Weynand B, Carrasco J, Lurquin C, Courtoy PJ, van der Bruggen P. A galectin-3 ligand corrects the impaired function of human CD4 and CD8 tumor-infiltrating lymphocytes and favors tumor rejection in mice. Cancer Res (2010), 70:7476-88.
    2. Bruyneel F, D’Auria L, Payen O, Courtoy PJ, Marchand-Brynaert J. Live-cell imaging with water soluble aminophenoxazinone dyes synthesized through laccase biocatalysis. Chembiochem (2010), 11:1451-7.
    3. Galland N, de Walque S, Voncken FG, Verlinde CL, Michels PAM. An internal sequence targets Trypanosoma brucei triosephosphate isomerase to glycosomes. Mol Biochem Parasitol. (2010), 171(1):45-9.
    4. Miranda L, Carpentier S, Platek A, Hussain N, Gueuning M-A, Vertommen D, Ozkan Y, Sid B, Hue, L, Courtoy PJ, Rider MH, Horman S. AMP-activated protein kinase induces actin cytoskeleton reorganization in epithelial cells. Biochem Biophys Res Commun (2010), 396:656-61.
    5. Veiga-da-Cunha M, Tyteca D, Stroobant V, Courtoy PJ, Opperdoes FR, Van Schaftingen E. Molecular identification of NAT8 as the enzyme that acetylates cysteine-S-conjugates to mercapturic acids. J Biol Chem (2010), 285:18888-98.
    6. Lima WR, Parreira KS, Devuyst O, Caplanusi A, N’Kuli F, Marien B, Van Der Smissen P, Alves PM, Verroust P, Christensen EI, Terzi F, Matter K, Balda MS, Pierreux CE*, Courtoy PJ*. ZONAB promotes proliferation and represses differentiation of proximal tubule epithelial cells.  (*, equal senior authors). J Am Soc Nephrol (2010), 21:478-88.
    7. Pierreux CE, Cordi S, Hick A-C, Achouri Y, Ruiz de Almodovar C, Prévot P-P, Courtoy PJ, Carmeliet P, Lemaigre FP. Epithelial:endothelial cross-talk regulates exocrine differentiation in developing pancreas. Dev Biol (2010), 347:216-27.
    8. Tissir F, Qu Y, Montcouquiol M, Zhou L, Komatsu K, Shi D, Fujimori T, Labeau J, Tyteca D, Courtoy PJ, Poumay Y, Uemura T, Goffinet  AM. Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nat NeuroSci (2010), 13:700-7.
    9. Tyteca D, D’Auria L, Van Der Smissen P, Medts T, Carpentier S, Monbaliu JC, de Diesbach P, Courtoy PJ. Three unrelated sphingomyelin analogs spontaneously cluster into plasma membrane micrometric domains. Biochim Biophys Acta Biomembranes (2010), 1798:909-27.
    10. Wiame E, Tyteca D, Pierrot N, Collard F, Amyere M, Noël G, Desmedt J, Nassogne M-C, Vikkula M, Octave J-N, Vincent M-F, Courtoy PJ, Boltshauser E, Van Schaftingen E. Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia. Biochem J (2010), 425:127-36.
    11. Medts T, de Diesbach P, Cominelli A, N'Kuli F, Tyteca D, Courtoy PJ. Acute ligand-independent Src activation mimics low EGF-induced EGFR surface signalling and redistribution into recycling endosomes. Exp Cell Res. (2010), 15;316(19):3239-53.

     

     

    PICT

    Platform for Imaging Cells and Tissues