PUBLICATIONS
2021
Kerselidou D, Dohai BS, Nelson DR, Daakour S, De Cock N, Hassoun ZAO, Kim DK, Olivet J, El Assal DC, Jaiswal A, Alzahmi A, Saha D, Pain C, Matthijssens F, Lemaitre P, Herfs M, Chapuis J, Ghesquiere B, Vertommen D, Kriechbaumer V, Knoops K, Lopez-Iglesias C, van Zandvoort M, Lambert JC, Hanson J, Desmet C, ThiryM, Lauersen KJ, Vidal M, Van Vlierberghe P, Dequiedt F, Salehi-Ashtiani K, Twizere JC,. Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells. Sci Adv (2021) 7(19):eabe8349.
Denis M, Dupas T, Persello A, Dontaine J, Bultot L, Betus C, Pelé T, Dhot J, Erraud A, Maillard A, Montnach J, Leroux AA, Bigot-Corbel E, Vertommen D, Rivière M, Lebreton J, Tessier A, Waard MD, Bertrand L, Rozec B, Lauzier B,. An O-GlcNAcylomic Approach Reveals ACLY as a Potential Target in Sepsis in the Young Rat. Int J Mol Sci (2021) 22(17):9236 .
Cesaro T, Hayashi Y, Borghese F, Vertommen D, Wavreil F, Michiels T. PKR activity modulation by phosphomimetic mutations of serine residues located three aminoacids upstream of double-stranded RNA binding motifs. Sci Rep (2021) 11(1):2045-2322.
van Caloen G, Schmitz S, van Marcke C, Caignet X, Mendola A, Pyr Dit Ruys S, Roger PP, Vertommen D, Machiels JP,. Preclinical Evaluation of the Association of the Cyclin-Dependent Kinase 4/6 Inhibitor, Ribociclib, and Cetuximab in Squamous Cell Carcinoma of the Head and Neck. Cancers (2021) 13(6):1251.
Dupas T, Denis M, Dontaine J, Persello A, Bultot L, Erraud A, Vertommen D, Bouchard B, Tessier A, Rivière M, Lebreton J, Bigot-Corbel E, Montnach J, De Waard M, Gauthier C, Burelle Y, Olson AK, Rozec B, Des Rosiers C, Bertrand L, Issad T, Lauzier B. Protein O-GlcNAcylation levels are regulated
independently of dietary intake in a tissue and time-specific manner during rat postnatal development.. Acta physiologica (2021) 231(3):e13566.
Henry C, Loiseau L, Vergnes A, Vertommen D, Mérida-Floriano A, Chitteni-Pattu S, Wood EA, Casadesús J, Cox MM, Barras F, Ezraty B. Redox controls RecA protein activity via reversible oxidation of its methionine residues. eLife (2010) 10.
He H, Denecker J, Van Der Kelen K, Willems P, Pottie R, Phua SY, Hannah MA, Vertommen D, Van Breusegem F, Mhamdi A. The Arabidopsis Mediator Complex Subunit 8 Regulates Oxidative Stress Responses. The Plant Cell, (2021).
Luo T, Pueyo JM, Wahni K, Yvanoff C, Lazar T, Pyr dit Ruys S, Vertommen D, Ezerina D, Messens J. Thiol-disulphide independent in-cell trapping for the identification of peroxiredoxin 2 interactors. Redox Biology (2021) 46(1):102066.
Spillier Q, Ravez S, Dochain S, Vertommen D, Thabault L, Feron O, Frédérick R. Unravelling the Allosteric Targeting of PHGDH at the ACT-Binding Domain with a Photoactivatable Diazirine Probe and Mass Spectrometry Experiments. Molecules (2021) 26(2):477.
2020
Pollet H, Cloos AS, Stommen A, Vanderroost J, Conrard L, Paquot A, Ghodsi M, Carquin M, Léonard AC, Guthmann M, Lingurski M, Vermylen C, Killian T, Gatto L, Rider MH, Pyr dit Ruys S, Vertommen D, Vikkula M, Brouillard P, Van Der Smissen P, Muccioli G, Tyteca D. Aberrant Membrane Composition and Biophysical Properties Impair Erythrocyte Morphology and Functionality in Elliptocytosis. Biomolecules (2020) 10(8):1120.
Li Z, Pinto Torres JE, Goossens J, Vertommen D, Caljon G, Sterckx YGJ, Magez S. An Unbiased Immunization Strategy Results in the Identification of Enolase as a Potential Marker for Nanobody-Based Detection of Trypanosoma evansi. Vaccines (2020) 8(3):415.
Ouni E, Pyr dit Ruys S, Dolmans MM, Herinckx G, Vertommen D, Andrade Amorim C. Divide-and-Conquer Matrisome Protein (DC-MaP) Strategy: An MS-Friendly Approach to Proteomic Matrisome Characterization. International Journal of Molecular Sciences (2020) 21(23):9141.
Hussain N, Chuang SJ, Johanns M, Vertommen D, Steinberg GR, ; Kemp BE, Rider MH. Effects of PKB/AKT inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue. The Biochemical journal (2020) 477(8):1373-1389.
Kopietz F, Rupar K, Berggreen C, Säll J, Vertommen D, Degerman E, Rider MH Göransson O. Inhibition of AMPK activity in response to insulin in adipocytes: involvement of AMPK pS485, PDEs, and cellular energy levels. American Journal of Physiology-Endocrinology and Metabolism, (2020) 319(3): E459-E471.
Murvai N, Kalmar L, Szalaine Agoston B, Szabo B, Tantos A, Csikos G, Micsonai A, Kardos J, Vertommen D, Nguyen PN, Hristozova N, Lang A, Kovacs D, Buday L, Han KH, Perczel A, Tompa P. Interplay of Structural Disorder and Short Binding Elements in the Cellular Chaperone Function of Plant Dehydrin ERD14. Cells (2020) 9(8):1856.
Gourgue F, Mignion L, Van Hul M, Dehaen N, Bastien E, Payen V, Leroy B, Joudiou N, Vertommen D, Bouzin C, Delzenne NM, Gallez B, Feron O, Jordan B, Cani PD. Obesity and triple-negative-breast-cancer: Is apelin a new key target?. Journal of cellular and molecular medicine (2020) 24:10233-44.
Liu Y, Nguyen PT, Wang X, Zhao Y, Meacham CE, Zou Z, Bordieanu B, Johanns M, Vertommen D, Wijshake T, May H, Xiao G, Shoji-Kawata S, Rider MH, Morrison SJ, Mishra P, Levine B. TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise. Nature (2020) 578(7796):605-609.
Tossounian MA, Khanh Truong AC, Buts L, Wahni K, Mourenza Á, Leermakers M, Vertommen D, Mateos LM, Volkov AN, Messens J. Methionine sulfoxide reductase B from Corynebacterium diphtheriae catalyzes sulfoxide reduction via an intramolecular disulfide cascade. J Biol Chem. (2020) 295(11):3664-3677.
van Caloen G, Schmitz S, El Baroudi M, Caignet X, Pyr Dit Ruys S, Roger PP, Vertommen D, Machiels JP. Preclinical Activity of Ribociclib in Squamous Cell Carcinoma of the Head and Neck. Mol Cancer Ther. (2020) 19(3):777-789.
Nguyen PN, Tossounian MA, Kovacs DS, Thu TT, Stijlemans B, Vertommen D, Pauwels J, Gevaert K, Angenon G, Messens J, Tompa P. Dehydrin ERD14 activates glutathione transferase Phi9 in Arabidopsis thaliana under osmotic stress. Biochim Biophys Acta Gen Subj. (2020) 1864(3):129506.
Yang D, Vandenbussche G, Vertommen D, Evrard D, Abskharon R, Cavalier JF, Berger G, Canaan S, Khan MS, Zeng S, Wohlkönig A, Prévost M, Soumillion P, Fontaine V. Methyl arachidonyl fluorophosphonate inhibits Mycobacterium tuberculosis thioesterase TesA and globally affects vancomycin susceptibility. FEBS Lett. (2020) 594(1):79-93.
Nguyen PN, Tossounian MA, Kovacs DS, Thu TT, Stijlemans B, Vertommen D, Pauwels J, Gevaert K, Angenon G, Messens J, Tompa P. Dehydrin ERD14 activates glutathione transferase Phi9 in Arabidopsis thaliana under osmotic stress. Biochim Biophys Acta Gen Subj. (2020) 1864(3):129506.
2019
Vermeulen M, Del Vento F, Kanbar M, Pyr Dit Ruys S, Vertommen D, Poels J, Wyns C. Generation of Organized Porcine Testicular Organoids in Solubilized Hydrogels from Decellularized Extracellular Matrix. Int J Mol Sci. (2019) 20(21) pii: E5476.
Marbaix AY, Chehade G, Noël G, Morsomme P, Vertommen D, Bommer GT, Van Schaftingen E. Pyridoxamine-phosphate oxidases and pyridoxamine-phosphate oxidase-related proteins catalyze the oxidation of 6-NAD(P)H to NAD(P). Biochem J. (2019) 476(20):3033-3052.
Huang J, Willems P, Wei B, Tian C, Ferreira RB, Bodra N, Martínez Gache SA, Wahni K, Liu K, Vertommen D, Gevaert K, Carroll KS, Van Montagu M, Yang J, Van Breusegem F, Messens J. Mining for protein S-sulfenylation in Arabidopsis uncovers redox-sensitive sites. Proc Natl Acad Sci U S A. (2019) 116(42):21256-21261.
Ouni E, Vertommen D, Amorim CA. The Human Ovary and Future of Fertility Assessment in the Post-Genome Era. Int J Mol Sci. (2019) 20(17). pii: E4209.
Deneyer N, Bridoux L, Bombled C, Pringels T, Bergiers I, Pyr Dit Ruys S, Vertommen D, Twizere JC, Rezsohazy R. HOXA2 activity regulation by cytoplasmic relocation, protein stabilization and post-translational modification. Biochim Biophys Acta Gene Regul Mech. (2019) 1862(9):194404.
Spillier Q, Vertommen D, Ravez S, Marteau R, Thémans Q, Corbet C, Feron O, Wouters J, Frédérick R. Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation. Sci Rep. (2019) 9(1):4737.
Lewandowska A, Vo TN, Nguyen TH, Wahni K, Vertommen D, Van Breusegem F, Young D, Messens J. Bifunctional Chloroplastic DJ-1B from Arabidopsis thaliana is an Oxidation-Robust Holdase and a Glyoxalase Sensitive to H₂O₂. Antioxidants (Basel). (2019) 8(1). pii: E8.
Tossounian MA, Wahni K, Van Molle I, Vertommen D, Astolfi Rosado L, Messens J. Redox-regulated methionine oxidation of Arabidopsis thaliana glutathione transferase Phi9 induces H-site flexibility. Protein Sci. (2019) 28(1):56-67.
Pecquet C, Chachoua I, Roy A, Balligand T, Vertenoeil G, Leroy E, Albu RI, Defour JP, Nivarthi H, Hug E, Xu E, Ould-Amer Y, Mouton C, Colau D, Vertommen D, Shwe MM, Marty C, Plo I, Vainchenker W, Kralovics R, Constantinescu SN. Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants. Blood. (2019) pii: blood-2018-09-874578.
Ouni E, Vertommen D, Chiti MC, Dolmans MM, Amorim CA. A Draft Map of the Human Ovarian Proteome for Tissue Engineering and Clinical Applications. Mol Cell Proteomics. (2019) 18:S159-S173.
2018
Goemans CV, Vertommen D, Agrebi R, Collet JF. CnoX Is a Chaperedoxin: A Holdase that Protects Its Substrates from Irreversible Oxidation. Mol Cell. (2018) 70(4):614-627.e7.
Drappier M, Jha BK, Stone S, Elliott R, Zhang R, Vertommen D, Weiss SR, Silverman RH, Michiels T. A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L. PLoS Pathog. (2018) 14(4):e1006989.
Bollaert E, Johanns M, Herinckx G, de Rocca Serra A, Vandewalle VA, Havelange V, Rider MH, Vertommen D, Demoulin JB. HBP1 phosphorylation by AKT regulates its transcriptional activity and glioblastoma cell proliferation. Cell Signal. (2018) 44:158-170
Kwiatkowski S, Seliga AK, Vertommen D, Terreri M, Ishikawa T, Grabowska I, Tiebe M, Teleman AA, Jagielski AK, Veiga-da-Cunha M, Drozak J. SETD3 protein is the actin-specific histidine N-methyltransferase. Elife. (2018)7. pii:e37921.
Wiame E, Tahay G, Tyteca D, Vertommen D, Stroobant V, Bommer GT, Van Schaftingen E. NAT6 acetylates the N-terminus of different forms of actin. FEBS J. (2018) 285(17):3299-3316.
2017
Johanns M, Pyr Dit Ruys S, Houddane A, Vertommen D, Herinckx G, Hue L, Proud CG, Rider MH. Direct and indirect activation of eukaryotic elongation factor 2 kinase by AMP-activated protein kinase. Cell Signal. 2017;36:212-221.
Herinckx G, Hussain N, Opperdoes FR, Storey KB, Rider MH, Vertommen D. Changes in the phosphoproteome of brown adipose tissue during hibernation in the ground squirrel, Ictidomys tridecemlineatus. Physiol Genomics. (2017);49(9):462-472.
2016
Collard F, Baldin F, Gerin I, Bolsée J, Noël G, Graff J, Veiga-da-Cunha M, Stroobant V, Vertommen D, Houddane A, Rider MH, Linster CL, Van Schaftingen E, Bommer GT. A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast. Nat Chem Biol. (2016) 12(8):601-7.
Arts IS, Vertommen D, Baldin F, Laloux G, Collet JF. Comprehensively Characterizing the Thioredoxin Interactome In Vivo Highlights the Central Role Played by This Ubiquitous Oxidoreductase in Redox Control. Mol Cell Proteomics. (2016) 15(6):2125-40.
Gerin I, Ury B, Breloy I, Bouchet-Seraphin C, Bolsée J, Halbout M, Graff J, Vertommen D, Muccioli GG, Seta N, Cuisset JM, Dabaj I, Quijano-Roy S, Grahn A, Van Schaftingen E, Bommer GT. ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto α-dystroglycan. Nat Commun. (2016) 7:11534
Johanns M, Lai YC, Hsu MF, Jacobs R, Vertommen D, Van Sande J, Dumont JE, Woods A, Carling D, Hue L, Viollet B, Foretz M, Rider MH. AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B. Nat Commun. (2016) 7:10856.
2015
Gennaris A, Ezraty B, Henry C, Agrebi R, Vergnes A, Oheix E, Bos J, Leverrier P, Espinosa L, Szewczyk J, Vertommen D, Iranzo O, Collet JF, Barras F. Repairing oxidized proteins in the bacterial envelope using respiratory chain electrons. Nature. (2015) 528(7582):409-412.
Pedre B, Van Molle I, Villadangos AF, Wahni K, Vertommen D, Turell L, Erdogan H, Mateos LM, Messens J. The Corynebacterium glutamicum mycothiol peroxidase is a reactive oxygen species-scavenging enzyme that shows promiscuity in thiol redox control. Mol Microbiol. (2015) 96(6):1176-91.
2014
Waszczak C, Akter S, Eeckhout D, Persiau G, Wahni K, Bodra N, Van Molle I, De Smet B, Vertommen D, Gevaert K, De Jaeger G, Van Montagu M, Messens J, Van Breusegem F. Sulfenome mining in Arabidopsis thaliana. Proc Natl Acad Sci U S A. (2014) 111(31):11545-50.
Wang X, Regufe da Mota S, Liu R, Moore CE, Xie J, Lanucara F, Agarwala U, Pyr Dit Ruys S, Vertommen D, Rider MH, Eyers CE, Proud CG. Eukaryotic elongation factor 2 kinase activity is controlled by multiple inputs from oncogenic signaling. Mol Cell Biol. (2014) 34(22):4088-103.
2012
Denoncin K, Schwalm J, Vertommen D, Silhavy TJ, Collet JF. Dissecting the Escherichia coli periplasmic chaperone network using differential proteomics. Proteomics. (2012) 12(9):1391-401.
2011
Linster CL, Noël G, Stroobant V, Vertommen D, Vincent MF, Bommer GT, Veiga-da-Cunha M, Van Schaftingen E. Ethylmalonyl-CoA decarboxylase, a new enzyme involved in metabolite proofreading. J Biol Chem. (2011) 286(50):42992-3003.
2009
Depuydt M, Leonard SE, Vertommen D, Denoncin K, Morsomme P, Wahni K, Messens J, Carroll KS, Collet JF. A periplasmic reducing system protects single cysteine residues from oxidation. Science. (2009) 326(5956):1109-11.
Vertommen D, Ruiz N, Leverrier P, Silhavy TJ, Collet JF. Characterization of the role of the Escherichia coli periplasmic chaperone SurA using differential proteomics. Proteomics. (2009) 9(9):2432-43.)
